JiaoTong University, China
Dr Hong-tao Wang,MD,an associate chief physician in division of cardiology, the Second Affiliated Hospital of Xi’an JiaoTong University.A member of Asia Pacific Heart Rhythm Society(ID numberï¼š108600896).Focused on the mechanism and management of the role of autonomic nervous system in the initiation and maintainence of atrial fibrillation.Published 2 papers collected by SCI as the first author (IF=4.2 and 1.3).Moreover, a paper was just published by JACC Clinical Electrophysiology in 2015.Gained Shaanxi Natural Science Fund in 2015.
Background: Heart failure (HF) and arrhythmia often coexist and share the similar underlying pathogenesis, including autonomic imbalance, electrical remodeling, and inflammatory reactions. Low-level electrical stimulation (LL-ES) rebalances the tone of the autonomic nervous system and has an anti-arrhythmic effect. However, it is unknown whether LL-ES can decrease the inflammatory response and benefit patients suffering from both HF and arrhythmia.
Aim: This study aimed to investigate the anti-arrhythmic and anti-inflammatory effects of LL-ES of aortic root ventricular ganglionated plexi (ARVGP).
Method: Twenty dogs were divided randomly into drug administration (control) and LL-ES groups after performing rapid right ventricle pacing to establish the HF model. The inducing rate of arrhythmia was measured after a programmed electrical procedure at the baseline and drug administration or LL-ES. The bioactive factors of HF, including angiotensin II, TGF-βï¼Œmitogen-activated protein kinase (MAPK), and matrix metalloproteinase (MMP), were assessed. Furthermore, ventricular size and left ventricular ejection fraction were determined.
Results: Compared with the control group, the inducing rate of arrhythmia decreased from 40% to 10% after 4 h of LL-ES (P < 0.05). The expression of angiotensin II, TGF-β, MAPK, and MMP was downregulated significantly in the LL-ES group (P < 0.05). Moreover, the volume of the left ventricle and the ejection fraction of the left ventricle in the LL-ES groupchanged little (P > 0.05).
Conclusion: Short-term LL-ES of ARVGP presented both anti-arrhythmic and anti-inflammatory effects and contributed to the treatment of HF and the associated arrhythmia.