2^nd Global Heart Congress

Biography:

Dr. Richard M. Fleming was born and raised in Iowa and is a "Kennedy Kid" receiving advanced scientific training through this program he received a formal education in Calculus and Particle Physics. He has received degrees in Physics, Biology, Chemistry and Psychology graduating second in his class, attended the University of Iowa College of Medicine graduating with High Honors; 1 of 17 Honors IM. He completed his law degree receiving class award for memorandum of law. While at Iowa he participated in human research, studying sodium and hypertension by measuring nerve conduction differentiating parasympathetic vs sympathetic responses. He completed internship, residency and a Cardiology fellowship in Houston where he published several papers on QCA, diets and heart disease and trained in Nuclear Cardiology including both SPECT & PET. He is one of three "certified" in PET imaging following a one year course of study on antimatter. He continued his investigation into the cause of heart disease and is the author and copyright holder of "Inflammation and Heart Disease," has been on The Today Show, MSNBC & 20/20. In 2005 he moved to the West Coast to help teach and train young physicians. His investigations have unmasked errors in the currently employed methods of detecting heart disease and breast cancer and has copyrights in both fields with patents pending on several methods to "quantitatively" detect these diseases thereby decreasing deaths, costs, time and radiation with associated risk of future cancer risks. He is currently expanding the use of these methods in the U.S., Canada, Europe and Asia. He has been involved with several Administrations as they relate to health care. He has published three independent books, Edited a Medical Textbook, has published several chapters in Medical Textbooks, and has more than 60 peer reviewed papers published in medical journals. He has presented more than 60 times in the U.S., Canada, Europe, the Mideast and Asia. He is credited as being the Father of Modern Nuclear Cardiology & Nuclear Medicine and The Theory of Inflammation and Heart Disease.

Abstract:

Background: The foundational work of nuclear cardiology and nuclear medicine began with Blumgarts 1925 study of “circulation time.” The method was actually quantitative yielding measurements of isotope over time. Unfortunately, the field of Nuclear Medicine and later Nuclear Cardiology would yield to an approach of qualitative image interpretation resulting in problems with sensitivity and specificity as do all “qualitative” methods, resulting in a 35% error rate, matching the limitations of anatomic assessment of disease, including but not limited to coronary angiography, mammography, CT/MRI, et cetera.

Methods: Three hundred men and women between ages 21 and 85 years of age were studied in five centers across the U.S. using a “quantitative” and “enhanced” method (FMTVDM©â„—) designed to measure isotope (Sestamibi and Myoview) redistribution to define “wash-in”, “washout” and “normal” redistribution. Results were compared to quantitative coronary angiography (QCA). Using FMTVDM redistribution measurements, percent diameter stenosis (%DS) was then calculated and the calculated %DS used to calculate a “quantified/Fleming coronary flow reserve”© (QCFR/FCFR) using proprietary equations. The result was then compared with the QCA derived measurements using best fit regression analysis.

Results: FMTVDM measurements of Sestamibi and Myoview redistribution produced a parabolic relationship (p<0.01) and showed that both Technetium 99-m isotopes redistribute beginning at 5-minutes post isotope infusion compared with the 60-minute distribution of isotope. Failure to correctly identify this timing of isotope redistribution had resulted in prior erroneous assumptions that Sestamibi and Myoview did not redistribute. Results from this redistribution was then used to calculate coronary artery narrowing (%DS) and QCFR/FCFR using the proprietary patent equations. The resulting “strong” relationship for the coefficient of determination was 0.87582 (p<0.0001).

Conclusion: Qualitative comparisons of nuclear imaging produces a diagnostic error rate of 35% comparable with angiographic errors in reader interpretation and the inability to satisfactorily unmask underlying vulnerable inflammatory plaques (VIPs) responsible for roughly 85% of all myocardial infarctions. FMTVDM©â„— provides the first ever “quantified” and “enhanced” method for measuring coronary artery disease (CAD) beginning with the measurement of isotope redistribution and ending with the calculation of QCFR/FCFR© using the patented proprietary equations. This patented method is applicable to any device capable of measuring isotope activity over time including but not limited to hand-held probes, planar, SPECT and PET. This provides the First “quantitative” and EVOLUTIONARY change for the fields of Nuclear Medicine and Nuclear Cardiology since its inception in 1925.